Nestled in downtown Louisville on historic West Main Street, the 21c Museum Hotel is a unique destination. This place is not just a hotel; it’s a contemporary art museum, a boutique hotel, and home to the renowned Proof on Main restaurant. Visitors are greeted by a striking double-size replica of Michelangelo’s David, and inside, they can explore captivating exhibitions and even sleep in art-inspired guest rooms. Housed in 19th-century warehouses, this space offers over 9,000 square feet of exhibition area, showcasing thought-provoking contemporary art that reflects global culture. The galleries are open every day, and the exhibitions change regularly, so guests can always find something new to discover.